Drug Safety Monitoring Board Recommends Expansion of Trial Population to Include 12 to 17 Year Old People with CF

Durham, NC (September 10, 2015) – Parion Sciences, a company dedicated to the development of novel treatments for pulmonary and ocular diseases, announced today that the CLEAN-CF enrollment criteria for the study of P-1037 would be expanded to include people with Cystic Fibrosis (CF) between the ages of 12 and 17 years of age. The trial had previously enrolled people with CF age 18 and above only. The expansion of the age criteria for enrollment was based on a pre-specified safety review by the Data Monitoring Committee (DMC).

READ THE ENTIRE PRESS RELEASE HERE ►

 – ENaC inhibition aims to restore or improve hydration of cell surfaces in the lungs to improve lung function –

– Parion to receive $80 million up-front payment with potential for additional development and regulatory
milestones and royalty payments –

BOSTON and DURHAM, NC — Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and Parion Sciences today announced that the companies will collaborate to develop investigational epithelial sodium channel (ENaC) inhibitors for the potential treatment of cystic fibrosis (CF) and other pulmonary diseases. Under the agreement, Vertex gains worldwide development and commercial rights to Parion’s investigational ENaC inhibitors, including P-1037 and P-1055, for CF and other pulmonary diseases. P-1037 is currently being evaluated in an exploratory Phase 2a study in people with CF, regardless of genotype, and Vertex and Parion plan to begin an additional Phase 2a study that adds P-1037 to treatment with the investigational combination of lumacaftor and ivacaftor for people with CF who have two copies of the F508del mutation. Parion will receive an $80 million up-front payment from Vertex with the potential to receive additional development and regulatory milestone payments and tiered royalties related to P-1037 and P-1055 in CF and other pulmonary diseases.

READ THE ENTIRE PRESS RELEASE HERE ►

Board of Directors Elect Paul Boucher as President and Chief Executive Officer

Durham, NC (April 19, 2015) – Parion Sciences, a company dedicated to the development of novel treatments for pulmonary and ocular diseases, announced today that Paul Boucher has been promoted to President and Chief Executive Officer. Paul previously served as President of Parion and will assume the Chief Executive Officer role as well.   Prior to his President role, Paul served as Vice-President of Finance & Business at Parion. Paul will continue to lead the executive management team and provide overall corporate direction.

Continue reading Parion Sciences Announces Key Management Promotion →

View Entire Article ►

Mucus.

Non-adolescents generally don’t think much about it until they’re suffering from allergies or a cold. For most people, you might say, ‘snot a big deal.

But a layer of protective mucus in sensitive bodily tissues plays a critical role in keeping our bodies healthy. People who have mucosal surface deficiencies suffer from conditions ranging from dry eye disease to life-threatening pulmonary diseases, including cystic fibrosis (CF), chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.

READ THE ENTIRE ARTICLE HERE

Continue reading Parion Sciences Announces $15.6 Million in Grant Support for Pulmonary Research Program →

Continue reading Parion Sciences Announces $3 Million Award from Cystic Fibrosis Foundation Therapeutics to Accelerate the Development of Novel CF Treatment →