Parion Sciences Announces Key Management Promotion

Board of Directors Elect Paul Boucher as President and Chief Executive Officer

Durham, NC (April 19, 2015) – Parion Sciences, a company dedicated to the development of novel treatments for pulmonary and ocular diseases, announced today that Paul Boucher has been promoted to President and Chief Executive Officer. Paul previously served as President of Parion and will assume the Chief Executive Officer role as well.   Prior to his President role, Paul served as Vice-President of Finance & Business at Parion. Paul will continue to lead the executive management team and provide overall corporate direction.

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Parion Sciences Announces Initiation of Phase 2 Clinical Study of P-1037 for the Treatment of Cystic Fibrosis

First Patient with Cystic Fibrosis Enrolled in CLEAN-CF Phase 2 Clinical Trial

Durham, NC (May 6, 2015) – Parion Sciences, a company dedicated to the development of novel treatments for pulmonary and ocular diseases, announced today it has begun enrollment of a phase 2 clinical trial of P-1037 in patients with Cystic Fibrosis (CF).

The trial has been named the “CLEAN-CF” trial which refers to “Clearing Lungs with ENaC inhibition in Cystic Fibrosis”. The CLEAN-CF study will include CF patients regardless of an individual’s genetic mutation. Inhibiting the epithelial sodium channels (ENaC) in the airways with P-1037, an “ENaC blocker,” is expected to re-hydrate the mucus layers, thus restoring airway clearance, improve lung function and, ultimately, reduce exacerbations. P-1037 has demonstrated to be long acting in preclinical models and to have a favorable safety and tolerability profile in the completed Phase 1 studies. The initiation of the Phase 2 clinical trials was supported by an award from Cystic Fibrosis Foundation Therapeutics Inc. (CFFT), the nonprofit affiliate of the Cystic Fibrosis Foundation.

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Parion’s $19.6M Inflow To Help Many Breathe Easier

Mucus.

Non-adolescents generally don’t think much about it until they’re suffering from allergies or a cold. For most people, you might say, ‘snot a big deal.

But a layer of protective mucus in sensitive bodily tissues plays a critical role in keeping our bodies healthy. People who have mucosal surface deficiencies suffer from conditions ranging from dry eye disease to life-threatening pulmonary diseases, including cystic fibrosis (CF), chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.

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