First Patient with Cystic Fibrosis Enrolled in CLEAN-CF Phase 2 Clinical Trial
Durham, NC (May 6, 2015) – Parion Sciences, a company dedicated to the development of novel treatments for pulmonary and ocular diseases, announced today it has begun enrollment of a phase 2 clinical trial of P-1037 in patients with Cystic Fibrosis (CF).
The trial has been named the “CLEAN-CF” trial which refers to “Clearing Lungs with ENaC inhibition in Cystic Fibrosis”. The CLEAN-CF study will include CF patients regardless of an individual’s genetic mutation. Inhibiting the epithelial sodium channels (ENaC) in the airways with P-1037, an “ENaC blocker,” is expected to re-hydrate the mucus layers, thus restoring airway clearance, improve lung function and, ultimately, reduce exacerbations. P-1037 has demonstrated to be long acting in preclinical models and to have a favorable safety and tolerability profile in the completed Phase 1 studies. The initiation of the Phase 2 clinical trials was supported by an award from Cystic Fibrosis Foundation Therapeutics Inc. (CFFT), the nonprofit affiliate of the Cystic Fibrosis Foundation.